Pharmaniaga Co-Amoxiclav Drug Interactions

Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use with amoxicillin/clavulanate may result in increased and prolonged blood levels of amoxicillin. Co-administration of probenacid cannot be recommended. The concurrent administration of allopurinol and ampicillin substantially increases the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. There are no data with amoxicillin/clavulanate and allopurinol administered concurrently. In common with other broad-spectrum antibiotics, amoxicillin/clavulanate may reduce the efficacy of oral contraceptives.
Prolongation of bleeding time and prothrombin time have been reported in some patients receiving amoxicillin/clavulanate and should be used with care in patients on anticoagulation therapy.